Characterization of a spliced exon product of herpes simplex type-1 latency-associated transcript in productively infected cells
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چکیده
منابع مشابه
Herpes Simplex Virus Type 1 Latency-Associated Transcript Reduces Human Neuroblastoma Cell Proliferation
Background and Aims: The latency-associated transcript (LAT) transcribed by latent Herpes Simplex Virus type-1 in neuron cells are able to influence their host cell pathways. While the most of previous studies were focused on anti-apoptotic effects of LAT, our investigation is making an effort to explore LAT potency on cell cycle pathway in neuroblastoma cell lines. Methods: The evaluation of L...
متن کاملThe latency-associated transcript gene enhances establishment of herpes simplex virus type 1 latency in rabbits.
The latency-associated transcript (LAT) gene the only herpes simplex virus type 1 (HSV-1) gene abundantly transcribed during neuronal latency, is essential for efficient in vivo reactivation. Whether LAT increases reactivation by a direct effect on the reactivation process or whether it does so by increasing the establishment of latency, thereby making more latently infected neurons available f...
متن کاملherpes simplex virus type 1 latency-associated transcript reduces human neuroblastoma cell proliferation
background and aims: the latency-associated transcript (lat) transcribed by latent herpes simplex virus type-1 in neuron cells are able to influence their host cell pathways. while the most of previous studies were focused on anti-apoptotic effects of lat, our investigation is making an effort to explore lat potency on cell cycle pathway in neuroblastoma cell lines. methods: the evaluation of l...
متن کاملThe herpes simplex virus type 1 latency-associated transcript gene regulates the establishment of latency.
Herpes simplex virus type 1 establishes latent infections in sensory neurons. During latency only one locus, the latency-associated transcript (LAT), is abundantly transcribed. Several lines of evidence suggest that this locus is required for the efficient reactivation from latency in experimental models. However, it is not yet clear whether this is a direct effect on the reactivation process p...
متن کاملIn vivo deletion analysis of the herpes simplex virus type 1 latency-associated transcript promoter.
During herpes simplex virus latency, transcripts accumulate from a single transcription unit of the viral genome. The promoter for these latency-associated transcripts (LAT) has been located, and a number of studies have documented the specific regions of this promoter which are important in transient assays of neuronal cells in culture. To examine the regulation of this promoter from the viral...
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ژورنال
عنوان ژورنال: Virology
سال: 2006
ISSN: 0042-6822
DOI: 10.1016/j.virol.2006.07.033